"Same Script, Different Cast" is a song performed as a duet by American and Canadian R&B singers Whitney Houston and Deborah Cox. The song was released as a single on October 10, 2000 by Arista Records. The song features Houston playing the former lover of Cox's current boyfriend. Houston warns Cox of his hurtful ways, though Cox refuses to acknowledge it.

The song incorporates a backing track of Ludwig van Beethoven's Für Elise during the intro. The song was released as a radio-only promo single and hence no video was made. It was a minor hit on Billboard Hot 100, peaking at number 70 while reaching number 14 on Hot R&B/Hip-Hop Songs. The song was also very successful on Hot Dance Club Play, peaking at number 4.